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The critical importance of epigenetics in autoimmune-related skin diseases
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 43-57 doi: 10.1007/s11684-022-0980-8
Keywords: epigenetics autoimmune-related skin diseases DNA methylation histone modifications noncoding RNAs
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 231-241 doi: 10.1007/s11684-013-0253-7
Keywords: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2
Regulation and function of histone acetyltransferase MOF
Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 79-83 doi: 10.1007/s11684-014-0314-6
Keywords: MOF histone acetyltransferase DNA damage repair tumorigenesis embryonic stem cells
Shixin ZHANG,Shaohua WU,Weimin TIAN
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4, Pages 357-362 doi: 10.15302/J-FASE-2016125
Keywords: Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,
Keywords: climacteric fruit ripening / phytohormones / TFs / epigenetic modifications
Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 79-90 doi: 10.1007/s11684-020-0783-8
Keywords: astragaloside IV brain ischemia natural killer cells histone deacetylase nuclear factor-κB
Yinglin JI, Mingyang XU, Aide WANG
Frontiers of Agricultural Science and Engineering Pages 314-334 doi: 10.15302/J-FASE-2021386
Keywords: climacteric fruit ripening phytohormones TFs epigenetic modifications
Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 153-157 doi: 10.1007/s11684-009-0034-5
Keywords: DNA methylation inhibitor histone deacetylase inhibitor bile duct carcinoma E-cadherin
Histone variants: critical determinants in tumour heterogeneity
Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 289-297 doi: 10.1007/s11684-018-0667-3
Keywords: cancer-testis TH2B TH2A H1T H1.0 H1F0 linker histones
Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li
Engineering 2021, Volume 7, Issue 10, Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014
The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose type. All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans. However, glycosylation did not directly contribute to the binding affinity between HCoV-19 S protein and hACE2. Additional post-translational modification (PTM) was identified, including multiple methylated sites in both proteins and multiple sites with hydroxylproline in hACE2. Refined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMs to recently published cryogenic electron microscopy structures. The PTM and glycan maps of HCoV-19 S protein and hACE2 provide additional structural details for studying the mechanisms underlying host attachment and the immune response of HCoV-19, as well as knowledge for developing desperately needed remedies and vaccines.
Keywords: N-glycosylation COVID-19 Spike protein hACE2 Structure
Title Author Date Type Operation
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Journal Article
Regulation and function of histone acetyltransferase MOF
Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li
Journal Article
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone
Shixin ZHANG,Shaohua WU,Weimin TIAN
Journal Article
ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS
Journal Article
suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone
Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang
Journal Article
ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS
Yinglin JI, Mingyang XU, Aide WANG
Journal Article
Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC
Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU
Journal Article
Histone variants: critical determinants in tumour heterogeneity
Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin
Journal Article